Search on: SUCCINATE-SEMIALDEHYDE DEHYDROGENASE 
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Descriptor English:   Succinate-Semialdehyde Dehydrogenase 
Descriptor Spanish:   Succionato-Semialdehído Deshidrogenasa 
Descriptor Portuguese:   Succinato-Semialdeído Desidrogenase 
Synonyms English:   NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase
Succinate Semialdehyde Dehydrogenase
Succinic Semialdehyde Dehydrogenase
Dehydrogenase, Succinate Semialdehyde
Dehydrogenase, Succinate-Semialdehyde
Dehydrogenase, Succinic Semialdehyde
Semialdehyde Dehydrogenase, Succinate
Semialdehyde Dehydrogenase, Succinic  
Tree Number:   D08.811.682.657.163.843
Definition English:   An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). 
History Note English:   2006(1980); use ALDEHYDE OXIDREDUCTASES 1977-1979 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   50619 
Unique Identifier:   D050644 

Occurrence in VHL:
 

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